AVONEX PACKAGE INSERT PDF

1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.

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Patients who develop dizziness, confusion, somnolence, and fatigue with interferon beta treatment should be cautioned to avoid driving or operating machinery.

Both interferon beta and interferon alpha are encoded on chromosome 9. The above list includes very serious side effects.

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It does not contain all the available information. Do not inject the area near the navel or waistline. If you are a female of childbearing age and are sexually active, you should use birth control during treatment with AVONEX. Alcohol may also potentiate drowsiness and dizziness.

Contact MS ActiveSource for more information —— Store at 2—8 degrees C 36—46 degrees F. Interrupt telbivudine if peripheral neuropathy is suspected, and discontinue the drug if peripheral neuropathy is confirmed.

What it looks like Each Solution for Injection blister tray contains:. Rebif is administered as a subcutaneous injection. Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. Tell your doctor or pharmacist if you notice anything that is making you feel unwell.

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Your doctor can discuss with you the possible risks involved. This allows the temperature of the medicine to approach room temperature. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Additionally, interferon beta-1a should not be used in patients with hamster protein hypersensitivity.

Closely monitor patients for treatment-associated toxicities, especially hematologic effects and hepatic decompensation, and manage as recommended for the individual therapies. Moderate Concurrent use of chloroquine and interferons is not recommended as there is an increased risk of retinal toxicity. Use only for the person for whom it has been prescribed. Hold syringe upright so that the rubber cap faces up. All products are for single-use only.

If he or she recommends that you take a medication to reduce symptoms of pain and inflammation, follow their advice carefully. Also, do not inject into skin that is red, irritated, bruised, or infected. Subcutaneous administration of the product is appropriate.

Interferons exist naturally in the body to help fight viral infections and regulate the body’s immunity. Major The concomitant use of interferons and nevirapine should be done with caution as both can cause hepatotoxicity. However, a small number of nursing mothers receiving interferon beta-1a reported no adverse effects in their partially breast-fed infants, and the amount of interferon beta-1a excreted into breast milk appeared to be insignificant.

Interferon beta increases the levels of 2,5-oligo-adenylate A synthetase, an intracellular enzyme that is capable of degrading viral RNA.

Avonex (interferon beta-1a) dose, indications, adverse effects, interactions from

In addition, interferon beta may bind to a distinct receptor that does not interact with interferon alpha. Nevirapine may cause liver damage in the context of hypersensitivity reactions or by direct toxic effects. Refer to the Patient Medication Guide for detailed instructions for oackage and giving a dose. A long-term paciage assessment was conducted at year 7 or 8 from the original PRISMS trial; data were available for of the patients and of the were still taking interferon beta-1a subcutaneously 3 times weekly.

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Unusual bleeding or bruising.

As an alternative, to reduce the incidence and severity of flu-like symptoms, treatment may be initiated with an IM dose of 7. A case of fulminant hepatic failure requiring liver transplantation in a patient who initiated interferon beta-1a therapy while taking other potentially hepatotoxic medications has been reported from a non-U.

Do avoned store for later use. Tell your doctor if you have or have had:. Patients treated with interferon beta should report immediately any symptoms of depression, suicidal ideation. For storage information, see specific product information within the How Supplied section.

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Continue the regular schedule but do not give 2 injections within aconex days of each other. Increased sweating or flushing. Ordinarily, multiple sclerosis MS patients receiving chronic immunomodulatory therapy should not be treated with natalizumab; however, in some multiple sclerosis clinical trials, patients were allowed to continue interferon beta therapy.

After counting to 10, pull the Pen straight out of the skin.

It may interfere with the results of some tests. There is no information on the use of this medicine in those below 12 years of age.