The present study aims at preparing an Emulgel formulation of Meloxicam using emulsifiers and various gelling agents along with the use of. PDF | Emulgel is one of the recent technologies in NDDS used for dual control release of emulsion and gel for topical use. The stability of. PDF | Topical therapies in cream, ointment, gel and lotion formulation, are an important component of dermatological therapeutic.

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Optimization of chlorphenesin emulgel formulation

This study was conducted to develop an emulgel formulation of chlorphenesin CHL using 2 types of gelling agents: The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgels was investigated using a 2 3 factorial design.

The prepared emulgels were evaluated for their physical appearance, rheological behavior, drug release, antifungal activity, and stability. Commercially available CHL topical powder was used for comparison. All the prepared emulgels showed acceptable physical properties concerning color, formuation, consistency, spreadability, and pH value. They also exhibited higher drug release and antifungal activity than the CHL powder.


It was found that the emulsifying agent concentration had the most pronounced effect on the drug release from the emulgels followed by the oil phase concentration and finally the type of the gelling agent. The drug release from all forulation emulgels was found to follow diffusion-controlled mechanism. Rheological studies revealed that the CHL emulgels exhibited a shear-thinning behavior with thixotropy. Stability studies showed that the physical appearance, rheological properties, drug release, and antifungal activity in all the prepared emulgels remained unchanged upon storage emulgle 3 months.

As a general conclusion, it was suggested that the CHL emulgel formulation prepared with HPMC with the oil phase concentration in its low level and emulsifying agent concentration in its high level was the formula of choice since it showed the highest drug release and antifungal activity. National Center for Biotechnology InformationU.

Published online Sep 1. Author information Article notes Copyright and License information Disclaimer. Received Dec 31; Accepted May This article has been cited by other articles in PMC. Abstract This study was conducted to develop an emulgel formulation of chlorphenesin CHL using 2 types of gelling agents: The Complete Drug Reference.


Optimization of chlorphenesin emulgel formulation

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Analysis of data on the medicament release from ointments. Support Center Support Center. Please review our privacy policy.